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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7904 | SR 19881 | Estrogen/progestogen Receptor | |
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay). | |||
T77549 | Nurr1 agonist 2 | Others | |
Nurr1 agonist 2 is a Nurr1 agonist with an EC50 value of 0.07 μM. Nurr1 agonist 2 increases the mRNA expression of the Nurr1-regulated genes tyrosine hydroxylase (TH) and vesicular amino acid transporter 2 (VMAT2). Nurr1... | |||
T8381 | Amodiaquine | Others , Histone Methyltransferase , Parasite | |
Amodiaquine is a synthetic aminoquinoline, used to treat malaria. | |||
T40349 | DS45500853 | ||
DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain ... | |||
T39916 | GNE-274 | ||
GNE-274, a non-degrader compound structurally similar to GDC-0927 (an ER degrader), serves as a partial ER agonist in breast cancer cell lines without triggering ER turnover. Notably, GNE-274 enhances chromatin accessibi... | |||
T73842 | Leriglitazone hydrochloride | ||
Leriglitazone (Hydroxypioglitazone) hydrochloride, a pioglitazone metabolite, acts as a PPARγ agonist, effectively stabilizing the PPARγ activation function-2 (AF-2) co-activator binding surface to enhance co-activator b... | |||
T60759 | DS20362725 | ||
DS20362725 is an agonist of estrogen-related receptor α (ERRα) that is able to be used for the metabolic disorders research, for example, type 2 diabetes mellitus (T2DM). The IC 50 value of DS20362725 inhibiting the bind... | |||
T22242 | Amodiaquine hydrochloride | ||
Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying... | |||
T83894 | 4A7C-301-Nurr1 Agonist | 4A7C-301-Nuclear Receptor-Related 1 | |
The compound 4A7C-301-Nurr1 agonist is a specific agonist for the nuclear receptor-related 1 (Nurr1). By binding to the Nurr1 ligand-binding domain with an IC50 value of 48.22 nM, it enhances the transcriptional activity... |